This activity in eTRIKS describes an effort to construct an integrated knowledge repository to provide biological context to data emerging from experimental studies for selected IMI projects. We envisage the disease areas to be respiratory, neurological and possibly rheumatoid arthritis. The project has three main aims:

  1. To construct networks that integrate multiple heterogeneous biological data sources to provide a database of background knowledge
  2. To construct detailed expert-verified metabolic and signaling pathways known to be involved in the disease condition
  3. To enable sharing and community curation of of these disease knowledge representations, using the NDex or other appropriate frameworks.

We anticipate that these research efforts will facilitate i) interpretation of new experimental data (such as differentially expressed genes) in the context of existing background knowledge such as pathways and protein interactions, ii) hypothesis generation by enabling mining of the complex networks to look for new unexpected relationships and iii) exploration of disease co-morbidity in terms of molecular mechanism.


This eTRIKS Labs module provided via this website is offered to the public as freely available resource, solely for non-commercial research use. Some aspects of this experimental module may still be under development, and is made available with no warranties about the completeness, reliability, accuracy and security of the software package or the services. Please bear this in mind, especially if you wish to analyse personal and/or confidential data.

This module uses public data and/or software sources that are available through third parties on the internet - these are identified by links provided under 'Acknowledgements'. If you use or re-distribute these public data or software for any purposes, you are responsible for adhering to the license requirements of these public data sources.